Causes of Sanfilippo syndrome

Sanfilippo syndrome — also known as mucopolysaccharidosis type III — is a rare life-threatening disorder that interferes with metabolism. While it doesn’t have a cure, some symptoms can be treated to alleviate this condition. Here’s everything you need to know as most of the Sanfilippo syndrome symptoms start at the age between 1 and 6 years — they include developmental delay, trouble sleeping, and frequent infections.This is gotten from an article from WebMD published on 20th of April 2022

Causes

Genetics: Both types of childhood Alzheimer’s are caused by genetics. The diseases are recessive, so both parents need to be a carrier of the gene for a child to inherit the condition.

Family history: increases the risk for Sanfilippo syndrome, which affects about 1 in 70,000 births.

Low buildup of GAG (glycosaminoglycans)

The body makes long chains of sugar molecules called glycosaminoglycans (GAGs), also called mucopolysaccharides. And when  present they can cause Sanfilippo syndrome.

Enzyme infection: There are four enzymes  involved in breaking down heparan sulfate, as there are also  four types of Sanfilippo syndrome (A, B, C, and D),so depending on which enzyme is affected. Type A is the most common and most severe form will cause Sanfilippo syndrome. All these causes are gotten from an article Nemours Kidshealth published on 19th Sept 2019.

In conclusion, There is no cure yet for Sanfilippo syndrome. But treatment focuses on easing symptoms and giving a child the best quality of life for as long as possible. Therefore if notice changes in a child, make sure to seek medical attention always .