Some 240 people were hurt in clashes as protesters tried to storm Georgia’s parliament after a Russian MP took the speaker’s seat in parliament.
Riot police stopped them from entering the building, reportedly using tear gas and rubber bullets.
Anger erupted when Sergei Gavrilov addressed an assembly of MPs from Orthodox Christian countries.
Tensions with Russia are high, 11 years after they fought a war over the breakaway region of South Ossetia.
More than 100 people were still being treated in hospital hours after the clashes on Friday, Georgian officials said. Among the 240 hurt, 80 were police, they added.
A doctor told Georgian media that two people had lost an eye.
Georgian President Salome Zourabichvili condemned Mr Gavrilov’s action as a “major crime” and appealed for calm.
Mr Gavrilov blamed the clashes on “fake news” in which he had been wrongly accused of fighting against Georgia in the early 1990s.
Russia’s foreign ministry accused Georgia’s opposition of trying to prevent an improvement in relations.
Mr Gavrilov was taking part in the Interparliamentary Assembly on Orthodoxy (IAO), a body set up by the Greek parliament in 1993 to foster relationships between Christian Orthodox lawmakers.
Opposition MPs in Georgia’s parliament called for protests in response to his decision to deliver a speech from the speaker’s seat.
He addressed delegates in Russian, angering politicians and Georgians vehemently opposed to Moscow’s presence in the country.
Calling for the Speaker, Irakli Kobakhidze, and other officials to resign, about 10,000 protesters breached the police cordon in the capital, Tbilisi, AFP reports.
Some were carrying EU flags and placards reading “Russia is an occupier”.
Giga Bokeria, an opposition MP for the European Georgia party, told AFP the rally outside parliament had been “a spontaneous protest by ordinary Georgians”.
