Two-time winners Ivory Coast edged past South Africa to make a winning start to their Africa Cup of Nations campaign on Monday.
Tunisia had to settle for a point against Angola, while Mali defeated tournament debutants Mauritania.
But what can we expect on day five?
Sport takes a closer look at the big stories surrounding Tuesday’s action.
Reigning champions Cameroon and four-time winners Ghana kick off their respective Group F campaigns in Ismailia on Tuesday.
The Indomitable Lions – managed by former Real Madrid and AC Milan midfielder Clarence Seedorf – play Guinea-Bissau at 18:00 BST.
The Black Stars, looking to end their 37-year wait for the trophy, then face a Benin side (21:00 BST) who are taking part in the tournament for the first time since 2010.