Osteogenesis imperfecta (OI), also known as brittle bone disease, is a connective tissue disease that makes your bones fragile and easily broken, with little or no force. It causes your body to make less type I collagen than it needs, or to make improperly formed collagen. The name osteogenesis imperfecta means “imperfectly formed bone.”
Causes
Hereditary
Anyone can be born with brittle bone disease. But you’re more likely to have OI if someone else in your biological family has it.
autosomal dominant pattern.
osteogenesis imperfecta are inherited Other types, they are inherited in an autosomal recessive or X-linked pattern. These informations are gotten from cleaveland clinics
Genetic variation (mutation)
Mutations in these genes impair normal bone development, causing the bones to be brittle and to fracture easily. These changes weaken connective tissues, leading to severe bone abnormalities and problems with growth.
Brittle bone
People who have brittle bone disease are born with it. They either don’t have enough collagen in their bones or the collagen doesn’t work as it should. This makes their bones weaker and more brittle than normal bones. It also can lead to abnormally shaped bones.
And finally, Complications may affect most body systems in a baby or child with OI. The risk of developing complications depends on the type and severity of your baby’s OI. Always contact your Healthcare provider for proper diagnosis and treatment.
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